Current payment channel newtorks (PCN) require nodes to stay permanently online and have enough resources to execute payment security mechanisms. Such assumptions are difficult to guarantee in battery-powered devices with intermittent connectivity patterns, such as mobile phones, smart objects, and sensors. In this thesis, we address the case of PCNs with resource-constrained devices on several fronts. First, we formalize a hybrid PCN model that considers light nodes and propose a mechanism to protect payment channels with resource-constrained devices. Next, we propose PCNsim, a simulator that replicates the main functionalities of a PCN in the OMNeT++ framework. Finally, we address the problem of routing payments from resource-constrained devices. We present a payment scheme that anticipates payment confirmations for time-sensitive applications and two routing algorithms that route payments considering application-specific constraints.